Professor Wesker
Fesh Pince of Blair
Jasper Batt Jr. from No More Heroes 2 is another. High pitched voice, a wimp who used other hitmen to kill people for him, has a battle that's just plain irritating, shares initials with Justin Bieber, and is voiced by Sasuke's voice actor? Suda did a great job meshing horrible things together to create a seriously unbearable character.
Case 3: One Piece's Spandam. I honestly loathe this guy like you wouldn't believe. He acts all high and mighty due to having an important government position but is a total coward when in a bad situation, and I can NOT stand people like that. While Kuro, Krieg, Arlong, Crocodile, Eneru, Blackbeard, and Akainu are all VERY prickish, at least they have strength to back it up. But the very thing that really pissed me off about this guy is how he treated Nico Robin while she was his prisoner. When I watched him beat the ever loving shit out of her while defenseless, I was STEAMED. I honest to god LOVE Robin, and you could SEE and FEEL her suffering and hurt at the hands of this bastard. Even Lucci was disgusted by him beating on a defenseless prisoner like that. No spoilers, but BOY was I glad once karma came to bite him in the ass, and by bite, I mean chomped!
And last but not least: Gary Oak. I fail to see why the fans adore him. I hate Ash and view him to be the equivilant of Ralph Wiggum from the Simpsons, at least he isn't an insufferable PRICK like Gary. His constant "Smell ya later!"s and cocky attitude always made me mad, and I honestly found his Pokémon Special equivalent to be as boring as all get out. At least you get to wipe the floor with his team on a daily basis. So, I'll be looking forward to hear who you guys hate with a burning passion!